Researcher finds possible strategy for killing cancer cells in children

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 4 2019In Belgium, there are 70,000 new adult cases of cancer every year, compared to 350 in children. Owing to lack of interest from pharmaceutical groups, treatments for pediatric cancers are developing much less rapidly than those for adults. The chemotherapy recommended for most childhood cancers is just as toxic as it was 20 years ago. In addition, it has significant consequences for the child: infertility, deafness, and premature aging. After chemotherapy sessions, the child suffers a loss of stem cells, which are crucial to the healing and regeneration of tissues. The cured child has an entire life to live, yet the capacity of his or her tissues to regenerate has diminished.For 15 years Anabelle Decottignies, a professor at the UCLouvain de Duve Institute, and her team have been studying telomeres, the little bits of chromosomes that play a vital role in aging. Normally, telomeres shorten over time, causing cells and organs to age. This is natural aging. In a cancer cell, telomeres don’t shorten. As a result, the cancer cells don’t age and they divide indefinitely, forming tumors and metastases.Prof. Decottignies’s goal is to target the cancer cell and safeguard the rest of the body, by forcing telomeres to shorten and thus prevent them from dividing. Achieving this necessitates understanding the mechanisms that allow cancer cells to maintain their eternal youth: * the team of Joris Messens, a professor at the VUB Center for Structural Biology, will identify molecules at the heart of the new therapy; * the team of Benjamin Elias, a chemist and professor at the UCLouvain Institute of Condensed Matter and Nanosciences, will synthesize the therapeutic molecules for ALT cancers. Related StoriesNew protein target for deadly ovarian cancerSugary drinks linked to cancer finds studyResearchers identify gene mutations linked to leukemia in children with Down’s syndromeRecently, the UCLouvain team identified a protein that allows the survival of cancer cells that use the ALT mechanism, which is not essential to the survival of healthy cells. Its name: TSPYL5. This protein is absolutely essential to the proper functioning of the telomeres of cancer cells that have the ALT mechanism, but not the telomeres of cells using telomerase or healthy cells. When the TSPYL5 protein is removed, the cancer cells die due to dysfunction of their telomeres. ‘This is the first time we have found a specific target to fight cancer cells in children’, Prof. Decottignies says.For the past year, Prof. Decottignies has been working with two other research teams to find new therapeutic molecules targeting TSPYL5: * In most cases, the cancer cells reactivate the expression of an embryonic gene. In the first stage of normal embryonic development, our cells are ‘eternally young’ thanks to the enzyme telomerase. In 90% of cancers, this enzyme can awaken, leading to tumors and metastases. * In 5 to 10% of cancer cases, most involving children, the cancer cells establish an alternative system based on a mechanism called alternative lengthening of telomeres (ALT). It is completely pathological – in other words, ALT is not active in any of our healthy cells, making it an ideal target for new anti-tumor therapies. Up next? Testing the molecules in culture and verifying in vitro that they kill ALT cancer cells and spare healthy cells. After that, preclinical tests will be done in mice. Finally, clinical trials in pediatric oncology will take place. For now, the first big challenge is to find molecules that kill only cancerous cells. The second will be to have very effective molecules that do not generate resistance from the cancer cell. If all these conditions are met, Prof. Decottignies’s team will have contributed to the improvement of treatments for pediatric cancers. Source:Université catholique de Louvainlast_img read more

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BMW to make electric MINIs in China with Great Wall Motor

first_imgBMW Group and China’s biggest SUV brand, Great Wall Motor, have announced a partnership to produce electric MINI vehicles in China. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Citation: BMW to make electric MINIs in China with Great Wall Motor (2018, July 10) retrieved 18 July 2019 from https://phys.org/news/2018-07-bmw-electric-minis-china-great.html © 2018 The Associated Press. All rights reserved. China auto sales rise 7.9 percent in May as electrics surge Tuesday’s announcement comes as automakers pour billions of dollars into creating electric models for China, the biggest market for the technology, under pressure from Beijing to accelerate development.BMW and Great Wall said the venture also will produce electric vehicles under the Chinese partner’s brand.Other automakers including General Motors Co., Volkswagen AG and Nissan Motor Co. have announced similar plans with local partners to produce dozens of electric models for China.last_img read more

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Ensure proper devolution to states KCR

first_imgSHARE SHARE EMAIL Union Budget Published on January 13, 2019 COMMENTS financial policycenter_img COMMENT Telangana The Finance Commission (FC) should become a policy formulating body to ensure proper devolution to states, according to Chief Minister K. Chandrashekar Rao.Speaking at a review meeting with officials ahead of the visit of the 15th Finance Commission to the state, Rao said the commission generally visits the states with “preconceived” notions.In view of rapid changes in the Indian economy, the functioning of the FC should not be a routine affair, he added.Though there have been different governments at the national and state level since Independence with different political parties, there has not been a qualitative change in Centre-state financial relations and, hence, it is time to introspect, the Chief Minister observed.”The broad fiscal policy lies with the Government of India. Whatever they are supposed to devolve, they have instead centralised,” Rao said.BUDGET While asking officials to prepare for a new Budget, theChief Minister said the state budget should be formulated only after defining “livelihood” as applicable to conditions in the state.While touching upon different aspects of the proposed budget, Rao said the money the government had spent during the past four years and next five years should be factored in.Describing Hyderabad as a global city, he said it needed a minimum of 100 urban parks and a master plan should be prepared. SHARElast_img read more

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f thats Trumps ide

If thats Trumps idea of success, I’m ready right now. quote, What’s your message to Ms. their duty is to unlawfully take people.

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He said he jumped a

He said he jumped after her but couldn’t find her,” Cohen said.

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